Platelet rich fibrin (PRF) is an autogenous matrix obtained from the patient’s platelet concentration. After a simple collection procedure and spinning the patient’s blood in a centrifuge in the clinic, we get a fibrin membrane which stimulates healing and growth of bones and soft tissue. It is rich in leukocytes and the vascular endothelial growth factor.
PRF also initiates permanent release of the platelet derived growth factor, a protein which plays a vital role in the angiogenesis process; beta–transforming growth factor, a protein which stimulates tissue growth; thrombospondin 1, an adjacent glycoprotein which participates in interactions between cells and in the angiogenesis process. The presence of these proteins significantly accelerates healing, especially in the critical phase during the first days after surgery.
The main advantage of this autogenous biomaterial is the slow release of growth factors from PRF which lasts more than 7 days. It may be done only from the RF membrane, but not from PRP or PRGF. The liquid drained from membranes is accumulated. It contains high numbers of proteins specialized in increasing the cell attachment to biomaterial and titanium.
In the clinical view, membranes have extraordinary properties. They are springy, resilient and flexible which makes it easy to manipulate them easily, cut and sew. PRF is exceptionally stable at a room temperature, which makes it possible to extend the working time. Membranes are very easy to create and are very similar to natural post-procedure fibrin networks. The biological and biomimetic quality of that membrane supports effective migration and cell proliferation and also eliminates the need to use biomechanical additions or anticoagulants.
It is very easy to create membranes and bone grafts at our facilities. it just requires the precise spinning protocol of a given level of the patient’s blood be strictly followed, and that membranes be drained and cut to the specified and fixed thickness. Welcome to the new era of bone graft and dental implant procedures at Americas Dental Care.